Children and adolescents with type 1 diabetes mellitus (T1DM) had a higher prevalence of psoriasis than children without T1DM, according to a letter to the editor published in the Journal of the European Academy of Dermatology and Venereology.
The letter discusses a study conducted in Italy between 2017 and 2018 to investigate a link between psoriasis and T1DM in children and adolescents. A single dermatologist examined T1DM patients at Padua University’s Pediatric Diabetes Center for the presence of psoriasis.
Of the 166 patients enrolled in the study, the mean age was 13.59 years, 45% were male, 23% were overweight or obese, the mean age at onset of T1DM was 6.32 years, and 16% had a family history of psoriasis.
In total, 8% pediatric patients were affected by psoriasis, a prevalence 4 times higher than in the general Italian pediatric population.
Study limitations included a small cohort and no control group matching age and BMI.
Psoriasis diagnoses coincided with, or were subsequent to, T1DM diagnoses, “suggesting a possible role of hyperglycemia in the onset of psoriasis in predisposed patients,” researchers wrote. They pointed to Th17 cells, which are believed to play a role in the pathogenesis of both T1DM and psoriasis, as a possible link between the two diseases.
Caroppo F, Galderisi A, Moretti C, Ventura L, Fortina AB. Prevalence of psoriasis in a cohort of children and adolescents with type 1 diabetes. JEADV. Published online April 29, 2021. doi:10.1111/jdv.17318