Primary repair of pediatrics retinal detachment

Introduction

Pediatric retinal detachment accounts for up to 5.9% of all rhegmatogenous retinal detachments (RRD).1–6 Many etiological factors have been reported as a cause of RRD in this age group including congenital anomalies, trauma, myopia, ocular surgeries including laser treatment and cryotherapy, and family history.7,8 In addition, many ocular and systemic conditions have been associated with RRD like Marfan syndrome, Stickler syndrome, congenital retinoschisis, retinopathy of prematurity and morning glory syndrome.8–14

The low success rate in repairing RRD in the pediatric age group stems from several reasons. One of them is the fact that trauma accounts for up to 50% of RRDs in the pediatric age group;15–17 it is understandable that the overall success rate would be less than that in adults. Furthermore, late presentation, anatomical features of the pediatric eyes, proliferative vitreoretinopathy, difficult vitreous separation, and the difficulty in maintaining a proper positioning in the postoperative period might lead to a lower success rate.18

Several series of pediatric retinal detachment have been reported with variable single surgery success rate (SSSR) ranging from 25 to 96% with limited data on comparing one procedure to the other.19–21 Hence the importance of evaluating the optimal surgical intervention with regard to outcome and complications is evident.

In this study, we are evaluating the outcomes of primary PPV vs SB-PPV in pediatric RRDs.

Methods

The study was carried at King Khaled Eye Specialist Hospital in Riyadh, Saudi Arabia. After approval from the institutional review board/ethics committee, we performed a retrospective analysis of all patients who underwent RRD repair between January 2014 and October 2018 in accordance with the Declaration of Helsinki. Patients’ informed consent was waived due to the retrospective nature of the study. Patients’ data confidentiality was maintained throughout the study. Inclusion criteria were patients who underwent repair of primary RRD under the age of 18 years with a minimum follow-up period of 12 months. Exclusion criteria were previous retinal surgery, previous pneumatic retinopexy, detachment related to intraocular infections or tumors and other causes of tractional or exudative retinal detachment.

A thorough chart review was done including demographic data, onset of the detachment (acute RRD defined as retinal detachment of less than one-month duration per history) and examination findings at the time of retinal detachment which included best corrected visual acuity, intraocular pressure, extent of detachment, macular involvement, number and type of breaks, involved quadrants). Visual acuity (VA) assessment was done using the Snellen chart or Sheridan Gardiner chart, as appropriate. For the purpose of analysis visual acuity was categorized into three groups: 20/20 to 20/40, 20/50 to 20/200, and less than 20/200)

Then operative notes were reviewed to obtain intraoperative findings, type of surgery, type of tamponade, dye used, ILM peel, laser vs cryotherapy. Postoperative follow-up visits findings were obtained at six, 12 months, and last follow-up visit to include retinal reattachment, best corrected visual acuity and development of postoperative complications including, but not limited to: cataract formation, elevated intraocular pressure (defined as IOP higher than 21 mmHg by applanation tonometry), proliferative vitreoretinopathy, epiretinal membrane formation.

All patients underwent 23-gauge pars plana vitrectomy with or without the addition of an encircling band. Different intraoperative tamponade agents were used. The study included surgeries done by multiple surgeons, including certified vitreoretinal surgeons and in-training fellows under direct supervision. Postoperative regiment was similar in both groups which included the use of topical antibiotics, mydriatic agents and topical steroids which was tapered according to the degree of postoperative inflammation.

Statistical analysis was done using SPSS 25.0, qualitative variables were represented as frequencies and percentages. Odds ratio, relative risk, chi-squared and Fisher’s exact test were used when appropriate.

Results

A total of 122 eyes of 117 patients were included in the study. Eighty eyes of 77 patients underwent pars plana vitrectomy alone (PPV group) and 42 eyes of 40 patients underwent PPV with scleral buckle (PPV-SB group). In the PPV group the mean follow-up period was 19.2 months ±11 months, while it was 18 months ±12 months in PPV-SB group (P=0.44). The mean age of the patients was 10.2±5.3 years vs 10.9±4.8 years in the PPV group vs PPV-SB group respectively (P=0.63).

The main cause of detachment in our patients was trauma which represented 45% in the PPV group vs 33.3% in the PPV-SB group P=0.25. Other causes of detachment include post surgeries, high myopia, syndromic detachment and spontaneous detachment. Variety of syndromes were associated with RRD in our study as illustrated in Table 1.

Table 1 Baseline Characteristics of Our Cohort of 117 Patients (122 Eyes)

Acute-onset RRD was found in 72.5% of the eyes in PPV group while it was found on only 26.2% of the eyes in SB-PPV group (P<0.001). We noticed that patients with PVR had been operated on with PPV-SB more often (26.3% in the PPV group vs 54.8% in the PPV-SB group, P=0.002). Phakic patients were more in the PPV-SB group, however this was statistically insignificant (92.9% in the PPV-SB group vs 86.3% in the PPV group, P=0.28) (Table 2).

Table 2 Intraoperative Findings for Both Groups PPV and PPV/SB

Regarding the characteristics of the detachment, there was no statistically significant difference between the two groups in the number of breaks, number of quadrants involved, rates of retinectomy, intentional retinotomy and the tamponade agents used. However, more cases with inferior breaks were in the PPV-SB group; 36% compared to 23% in the PPV group (P=0.04).

Single surgery success rate (SSSR) was 76.3% (n=61) and 66.7% (n=28) (P=0.45) for PPV and PPV-SB respectively. Among the 33 cases that were not successful with the first surgery, nine cases had incomplete vitreous separation (27%); four in the PPV group and five in the PPV-SB group. There was no significant difference in SSSR between the two groups, PPV and PPV-SB, when looking into the eyes based on the chronicity (acute vs chronic detachment), the etiology and the status of PVR (present vs absent) (Table 3). Further analysis was done for cases with inferior breaks which showed comparable results in both groups; SSSR of 75% in PPV group and 73% in PPV-SB group.

Table 3 Single Surgery Success Rates According to Chronicity, Status of PVR and Etiology

After the second surgery the success rate was 93.8% in the PPV group vs 92.7% in the PPV-SB group. Table 4 shows the number of surgeries needed in each group.

Table 4 Number of Reattachment Surgeries and the Success Rate

Overall, 82.5% of PPV and 83.3% of PPV-SB cases were done by vitreoretinal consultants. In contrast, 97.7% of cases with PVR were done by consultants (either PPV or PPV-SB) and 74% of cases without PVR were done by consultants.

Preoperative VA was measurable in 82.5% of patients in both the PPV and the PPV-SB groups. In the PPV group, 20% of patients had VA better than 20/200, which increased to 33.8% at the last follow-up visit (P=0.019). While in the PPV-SB group: 9.5% of patients had VA better than 20/200 at presentation which increased to 40.5% at the last follow-up (P=0.004). No statistical significance was found in the postoperative VA between consultants and fellows (Table 5).

Table 5 Initial and Final BCVA in PPV and PPV-SB Groups

The overall rate of postoperative complications at six months was 37% and was slightly higher in the PPV-SB group (42.9%) in the six-month follow-up compared to the PPV group (33.8%) with no statistically significant difference (P=0.322). At the last follow-up visit (last follow-up was at a mean of two years ±11 months), the rate was almost equal in both groups; 31% for PPV-SB vs 32.5% for PPV (P=0.0.862) since some complications like cataract and epiretinal membranes were managed surgically. A full list of complications is demonstrated in Table 6.

Table 6 Rate of Postoperative Complications

Discussion

This study is trying to address the role of PPV with or without SB in treating primary pediatric RRDs. PPV vs PPV-SB has been evaluated previously in adult RRD. However, to our knowledge a similar comparison in the pediatric age group was not studied before.

At the initial look of baseline characteristics of the eyes in both groups, we noticed significant differences at the distribution of eyes with acute RRD being more subjected to PPV alone. This indicates surgeon’s preference toward PPV alone in cases of acute RRD. On the contrary, in chronic RRD, surgeons in our cohort tend to combine PPV with scleral buckle as chronic RRD was considered a complicated case. However, we analyze the success rate of acute and chronic RRD separately among the two groups PPV vs PPV-SB, which showed no significant difference (P=0.78) in subgroups analysis table.

Primary success rate was slightly higher in the PPV group regardless of the etiology (76.3% vs 66.7%; P=0.45) with no statistical significance. However, with one additional surgery, the rates became comparable in both groups. In concordance with our result of the success rate, Al-Zaaidi21 reported SSSR in pediatric RRDs of 63% that increased to 80% with multiple reattachment surgeries, regardless of the type of primary surgery. In our series, however, we noticed a tendency toward doing PPV-SB in the presence of chronic RRD, presence of inferior breaks and presence of PVR. Chronic RRDs (73.8%) underwent PPV-SB compared to 26.3% of chronic RRDs in PPV alone. The same was found in PVR where in the PPV-SB group 55% of the eyes had preoperative PVR, compared to only 26.3% in the PPV group. However, the result of the subgroup analysis did not show significant difference between the two types of intervention PPV alone vs PPV-SB in the final outcome. Despite the fact that what has been labeled as chronic detachment and the presence of PVR might not be of equal stage. When looking in the location of breaks, eyes with inferior breaks were more in the PPV-SB group (P=0.04). This coincides with a previous report by Orlin et al22 who reported similar surgeons’ preference of performing PPV-SB in eyes with inferior breaks but they did not find a difference in the SSSR between both interventions; adding an encircling band did not increase the SSSR. Alexander et al23 proposed that supplementing PPV with a scleral buckle might increase the success rates in eyes with inferior breaks. In their study the SSSR was 95% at three months. However, there was no control group in their study and their results were compared to the previously published reports.

In our cohort, there was no statistically significant difference in regard to the lens status and the performed surgery with phakic eyes being more in the PPV-SB group. This is a point of controversy where some might prefer to place an encircling band in phakic patients due to the difficulty of properly shaving the peripheral vitreous while others prefer to place it in aphakic/pseudophakic eyes due to the possibility of the presence of small undetectable breaks.22 Kinori et al24 and Orlin et al22 concluded that based on lens status, PPV-SB is comparable to PPV alone and Weichel et al25 PPV-SB and PPV have comparable results in pseudophakic eyes.

Pediatrics are considered at a higher risk of developing PVR compared to adults.26 When looking into the presence of PVR and its effect on SSSR, it was unexpectedly almost equal whether PVR is present or absent. Storey et al27 compared PPV alone vs PPV-SB in adult RRD at a high risk of PVR. They reported SSSR for PPV-SB to be 75% compared to 48% for PPV alone. Our unexpected results can be explained by the fact that 97.7% of PVR cases were operated on by experienced consultants compared to 74% of cases without PVR.; the more experienced the surgeon, the higher the success rate.

Visual outcome seems to be better in the PPV-SB group. However, the PPV-SB group had a significantly worse preoperative visual acuity and despite the anatomical success, visual improvement might not be a sequel. Al-Zaaidi21 reported 50% lack of visual improvement and McElnea et al17 reported 60% lack of visual improvement or even worsening visual acuity postoperatively. Furthermore, visual improvement in pediatrics RRD is related to other factors like amblyopia therapy, aphakia correction, reliable measure of visual evaluation in this age group.

Overall, the rate of postoperative complications in our cohort (37%) was less than that previously reported by Al-Zaaidi21 (64.5%). Postoperative complications were slightly higher in the PPV-SB group; 43% compared to 34% in the PPV group. However, this high rate was attributed mainly to cataract formation. Weichel et al25 reported postoperative complications of 32% in the PPV-SB group and 19% in the PPV group. However, their study included only noncomplex RRD and adult patients. The rate of PVR formation was comparable in both groups (at six months; 4.8% in the PPV-SB group and 3.8% in the PPV group) and comparable with other published studies in pseudophakic RRDs (6–17%).25,28–30 One case underwent phthisis bulbi in the PPV group, the etiology of detachment in this eye was open globe injury. Open globe injury related detachments have poorer prognosis compared to other types of detachments. Sindal et al31 reported prethisis to be as high as 33% in open globe injuries and Sarrazin et al32 reported a reattachment rate in open globe injuries of 46%.

The limitations of our study include its retrospective nature and the imbalance in the baseline characteristics. The later was overcome by comparing similar subgroups among both interventions separately. Furthermore, the procedure selection (either PPV vs PPV-SB) was performed based on each surgeon’s own preference and experience.

In conclusion, PPV and PPV-SB has comparable results in regard to anatomical success and rate of postoperative complications despite the fact that complicated cases were more in the PPV-SB group which highlights that there might be a perceived value of scleral buckle with PPV among the surgeons in our cohort in complex pediatric RRDs.

Acknowledgments

Other Acknowledgments: Dr Abeer Ahmad, Biostatistician in Research Department, King Khaled Eye Specialist Hospital.

Funding

No funding was granted for this article.

Disclosure

The authors report no conflicts of interest in this work and no financial disclosures.

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