Cancer-busting broccoli sprout pills in space, trauma and healing among Indigenous people, how to boost HPV vaccinations

SEATTLE – August 3, 2021 – Below are summaries of recent research findings from Fred Hutch and other news.

Join our next public science event, “Back to the Future: Navigating Work, School, and Wellness in a World Changed by COVID-19.” The virtual discussion is on Tuesday, Aug. 10 from 11 a.m. to noon PT and will feature Drs. Trevor Bedford, Josh Hill and Alpana Waghmare. Then respond HERE before Monday 9 August.

Fred Hutchinson Cancer Research Center, Seattle Children’s and UW Medicine Lay the Groundwork for Historic Cancer Partnership
Fred Hutchinson Cancer Research Center, UW Medicine, Seattle Cancer Care Alliance and Seattle Children’s have announced plans to explore the restructuring of their long-term relationship to pursue a shared mission of advancing diagnosis, treatment and breakthrough treatments for cancer and other diseases. accelerate. The proposed restructuring, if completed and approved, would create an adult-focused oncology program and, separately, a pediatric oncology program.
Media contact: Shelby Barnes, mrbarnes@fredhutch.org

cancer research

Cancer Fighting Broccoli Germ Pills? It’s one thing.
Translational scientist Dr. Thomas Kensler has been looking for a way to tap into the powerful cancer-fighting process that is activated when you eat cruciferous vegetables. His research on “green chemoprevention” stretches from eastern China to Seattle and now into space.
Media contact: Kat Wynn, kwynn@fredhutch.org

Overlooked stretches of DNA may hide cancer-causing mutations
A new advanced technique sheds light on difficult-to-study DNA regions and potential drug targets. Fred Hutch scientists have shown that the often-overlooked regions flanking our genes harbor mutations that can disrupt normal protein production and affect tumor spread and response to treatment. This new work reveals an underappreciated aspect of cancer biology and could become the focus of future drug discovery efforts.
Media contact: Molly McElroy, mwmcelro@fredhutch.org

health differences

Cancer Health Equity Now: Grief, Intergenerational Trauma and Healing Among Indigenous People
A new podcast episode from Fred Hutch’s Office of Community Outreach and Engagement focuses on the impact of unresolved grief and intergenerational trauma and its impact on the health of Indigenous people. Ursula Tsosie, Program Manager and Tribal Liaison for the Seattle Cancer Care Alliance, spoke with Leona Swamp, of the Wolf Clan of the Akwesasne Mohawk Nation. Swamp is the Executive Director of Aseshate:Ka’te Grief Services, a non-profit organization that focuses on helping Indigenous people cope with their grief in a safe and supportive environment, while also applying traditional teachings.
Media contact: Claire Hudson, crhudson@fredhutch.org

Income and health-related quality of life in colorectal cancer survivors
A new study from the Fred Hutch Division of Public Health Science’s Newcomb Group followed colorectal patients to better tolerate their quality of life after diagnosis. Early detection and effective treatments provided increased survival rates in colorectal cancer survivors. Still, survivors with a favorable prognosis may have poor health because of the physical, psychosocial, and financial burden of a colorectal diagnosis, especially if colorectal cancer recurs.
Media contact: Kat Wynn, kwynn@fredhutch.org

COVID-19

Hospitals in Uganda receive much-needed COVID-19 supplies from the Seattle area
When vaccination rates reached 70% of adults in Washington state, half a ton of Fred Hutch hospital supplies were shipped by air to Uganda, where COVID-19 is raging. Vaccines are not widely available in Uganda and many patients being treated for cancer at the UCI-Fred Hutch Cancer Center in Kampala have active coronavirus infections. This shipment of more than 10,000 pieces of PPE will help protect healthcare professionals and staff managing patients at Uganda Cancer Institute.
Media contact: Claire Hudson, crhudson@fredhutch.org

How coronavirus immunity studies could yield better vaccines and treatments
The new coronavirus is here to stay — we know that. There’s still a lot we need to figure out. How often should vaccines be updated? How often should we get boosters? We have the power to shape the answers to these questions through the strategies we use to develop vaccines and immune therapies against the COVID-19 virus. Scientists are looking for broad-spectrum antibodies that could protect against new variants of SARS-CoV-2 — and perhaps a future SARS-3.
Media contact: Molly McElroy, mwmcelro@fredhutch.org

Deleted SARS-CoV-2 sequences from early Wuhan outbreak provide clues
Evolutionary biologist Dr. Jesse Bloom discussed how he found SARS-CoV-2 sequences from the start of the Wuhan outbreak and why it’s important to continue gathering information about how the pandemic started.
Media contact: Molly McElroy, mwmcelro@fredhutch.org

Latest Fred Hutch investigation into COVID-19
In this latest roundup of recent COVID-19 news, a study published July 29 in JAMA Network Open on enrollment during the COVID-19 pandemic for cancer clinical trials conducted by the SWOG Cancer Research Network reported, a cancer clinical research group funded by the National Cancer Institute. Led by Dr Joseph Unger, a biostatistician based in Fred Hutch, the researchers found that during the early weeks of the pandemic, from late February to mid-April 2020, overall cancer clinical trial registrations declined rapidly compared to previous years. .
Media contact: Claire Hudson, crhudson@fredhutch.org

Vaccine and Infectious Disease

New study finds many cancer patients have no antibodies against measles or mumps
To find out how much protection cancer patients have against measles and mumps, physician scientist Dr. Steve Pergam and biostatistician Elizabeth Krantz in 2019 a project to assess the levels of antibody protection against those viruses in that population. Pergam and his colleagues know that measles is much more contagious than SARS-CoV-2, and if an outbreak were to occur, it would pose a serious threat to cancer patients. The study found that one in four cancer patients tested had no protective antibodies against measles, and more than one in three against mumps.
Media contact: Claire Hudson, crhudson@fredhutch.org

The Challenge of Completing HPV Vaccine Series
Human papillomaviruses (HPV) cause the vast majority of cervical cancers and are associated with six cancers. Since 2006, a highly effective and safe vaccine has been available in the United States that prevents both infections with oncogenic HPV types and HPV-associated cancers in a multi-dose regimen that varies by age. Yet in 2019, only 54.2% of adolescents had an up-to-date HPV vaccination. A new study by Fred Hutch in collaboration with the Kaiser Permanente Washington Health Research Institute suggests more communication and awareness is needed to encourage people to complete the series.
Media contact: Claire Hudson, crhudson@fredhutch.org

basic sciences

Good fat, bad fat, intestinal fat, gonad fat
In a new paper, the Priess Lab examined an unusual form of fat storage in our bodies. Even in fit and healthy people, fat is found almost everywhere. It’s under our skin, around our internal organs, even in the cytoplasm of our cells in the form of lipid droplets. One place that is not classically considered a place where fat is located is the cell nucleus. To better understand this unexpected phenomenon, the study looked at nuclear fat in a nematode.
Media contact: Molly McElroy, mwmcelro@fredhutch.org

Other noteworthy news

Heart of the Hutch Series: Global Employees and Dedicated Supporters

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At the Fred Hutchinson Cancer Research Center, home to three Nobel Prize winners, interdisciplinary teams of world-renowned scientists search for new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which uses the power of the immune system to treat cancer. Fred Hutch, an independent, nonprofit research institute based in Seattle, houses the first National Cancer Institute-funded cancer prevention research program, as well as the clinical coordination center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network and the COVID-19 Prevention Network.

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